Interleukin 17 in vascular inflammation
نویسندگان
چکیده
منابع مشابه
Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice.
OBJECTIVE Interleukin 17A (IL17A) is involved in many inflammatory processes, but its role in atherosclerosis remains controversial. We examined the role of IL17A in mouse and human atherosclerosis. METHODS AND RESULTS Atherosclerosis was induced in apolipoprotein E (ApoE)(-/-) and IL17A/ApoE(-/-) mice using high-fat feeding, angiotensin II infusion, or partial carotid ligation. In ApoE(-/-) ...
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OBJECTIVE Interleukin (IL)-17A is regarded as an important cytokine to drive psoriasis, an inflammatory skin disease marked by increased cardiovascular mortality. We aimed to test the hypothesis that overproduction of IL-17A in the skin leading to dermal inflammation may systemically cause vascular dysfunction in psoriasis-like skin disease. APPROACH AND RESULTS Conditional overexpression of ...
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Atherosclerotic vascular disease (ASVD) involves several overlapping pathological processes. Atherogenesis, the process by which atherosclerotic plaques develop in the arterial wall, involves inspissation of abnormal circulating lipoproteins into the vessel intima, resulting in inflammation, injury, and responses to injury.1 Mouse models of atherogenesis, involving impaired low-density lipoprot...
متن کاملSerum Interleukin-17 Evaluation in Patients With Eosinophilic Gastrointestinal Disease
Background: Eosinophilic gastrointestinal disorders or diseases (EGIDs) may result from an abnormal immune-mediated response to food antigens. Activated eosinophils release various mediators with inflammatory properties which may result in tissue and subsequently organ damage. The cytokine milieu of these patients has revealed increased levels of pro-inflammatory cytokines, inc...
متن کاملCytokines, interleukin-18, and the genetic determinants of vascular inflammation.
Inflammation and Vascular Disease In the past decade, atherogenesis has become recognized as an active, inflammatory vascular process rather than simply the result of passive endothelial injury with subsequent lipid infiltration.1 Evidence of inflammation is found locally in the vascular wall and systemically in the circulation. Participants in the inflammatory process within atherosclerotic pl...
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ژورنال
عنوان ژورنال: Cytokine & Growth Factor Reviews
سال: 2010
ISSN: 1359-6101
DOI: 10.1016/j.cytogfr.2010.10.003